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2013 AACR - Program

Program

This first joint meeting between the AACR and the Society of Nuclear Medicine and Molecular Imaging will bring together imaging scientists with biologists in basic, translational, and clinical research to explore how new findings in molecular imaging can improve cancer diagnostics, treatment, and patient outcomes. Sessions will cover areas of cancer biology that currently, or will potentially, interface with molecular imaging technologies and/or imaging agent development. With a speaker roster of expert molecular imaging scientists, cancer biologists, chemical engineers, radiation oncologists, and systems biologists, the conference will provide an interdisciplinary forum and encourage new collaborations.

Continuing Medical Education Activity AMA PRA Category 1 CreditsTMavailable.
Please review the complete CME Accreditation statement.

CLAIMING (CME) CREDIT

Physicians and other health care professionals seeking AMA PRA Category 1 Credit(s)TM for this live continuing medical education activity must complete the online CME Request for Credit Survey by Monday, April 15, 2013. Certificates will only be issued to those who complete the survey. Your CME certificate will be sent to you via email after the completion of the activity.

 

View the Scientific Abstracts

Meeting Information

This conference will be held at the Manchester Grand Hyatt San Diego in San Diego, CA. 

Manchester Grand Hyatt San Diego
One Market Place,
San Diego, California, USA 92101 
Tel: +1 619 232 1234
Experience San Diego, CA

Agenda

February 27, 2013
Time Session Title
1:00-3:00 pm Concurrent Educational Sessions 1& 2

Concurrent Educational Session 1:  Imaging Therapeutic Response - Randle Ballroom D

Imaging therapeutic response with PET
Wolfgang Weber, Memorial Sloan-Kettering Cancer Center, New York, NY

Assessing and monitoring therapeutic response of breast and cervical cancer with FDG-PET
Farrokh Dehdashti, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO

Imaging the role of the immune system during oncogene induced tumorigenesis
Dean W. Felsher, Stanford University, Stanford, CA

MRI to track breast cancer treatment and the I-SPY/ACRIN trials
Nola Hylton, University of California, San Francisco

Concurrent Educational Session 2:  Emerging Technologies - Randle Ballroom E

Cerenkov luminescence imaging: A new tool for molecular imaging?
Simon R. Cherry, University of California, Davis, CA

Targeted microbubbles: Ultrasound Contrast Agents for Molecular Imaging
Alexander L. Klibanov, University of Virginia, Charlottesville, VA

Imaging glutaminolysis in cancer
Hank F. Kung, University of Pennsylvania, Philadelphia, PA

Mouse lung cancer co-clinical trials
Kwok-Kin Wong, Dana-Farber Cancer Institute, Boston, MA

3:30 - 5:30 pm Educational Session 3 & 4

Concurrent Educational Session 3:  In Vivo Studies of Cancer Biology at Cellular Resolution - Randle Ballroom D

Photoacoustic tomography: Ultrasonically breaking through the optical diffusion limit
Lihong Wang, Washington University, St. Louis, MO

Optical imaging at the nanometer scale: Studies of molecular structures and interactions
Alexandros Pertsinidis, Memorial Sloan-Kettering Cancer Center, New York, NY         

Molecular endoscopy for detection of neoplasia in the digestive tract
Thomas D. Wang, University of Michigan, Ann Arbor, MI


Cancer imaging to overcome delivery barriers and validate “omic” targets in vivo
Jan E. Schnitzer, PRISM, San Diego, CA

Concurrent Educational Session 4:  Sponsored by the World Molecular Imaging Society (WMIS) - Multi-modal imaging: Challenges and Opportunities in Cancer Discovery and Treatment - Randle Ballroom E

Session Co-Chair: Juri G. Gelovani, Biomedical Engineering and Karmanos Cancer Center, Wayne State University, Detroit, MI.

MR metabolic imaging: challenges and opportunities in cancer
Sabrina Ronen, University of California, San Francisco, CA

Molecular receptor imaging with integrated MR and optical
Brian W. Pogue, Thayer School of Engineering at Dartmouth, Hanover, NH

Multi-modal cancer imaging: Roles of the optical imaging
Hisataka Kobayashi, National Cancer Institute, Bethesda, MD

5:30 - 7:00 pm Dinner on own
7:00 - 8:00 pm

Opening Keynote Session - Randle Ballroom D/E

Hallmarks of cancer: From concepts to therapy (and imaging)
Douglas Hanahan, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

8:00 - 9:30 pm Welcome Reception/Exhibitor Hours
 
February 28, 2013
Time Session Title
7:00 - 8:00 am Continental Breakfast - Randle Royer/Terrace
8:00 - 10:00 am

Plenary Session 1: Visualizing the Cancer Stem Cell - Randle Ballroom D/E
Session Chairperson:  Carolyn J. Anderson, University of Pittsburgh Medical Center, Pittsburgh, PA

Cancerous stem cells with genomic instability: The best vehicle with the best engine for cancer
Eric Lagasse, University of Pittsburgh Medical Center, Pittsburgh, PA

Imaging the cancer stem cell marker AC133
Gabriele Niedermann, University of Freiburg, Freiburg, Germany

In vivo imaging of the hematopoietic stem cell niche
Charles P. Lin, Massachusetts General Hospital, Boston, MA

111In-360 mAb modified with nuclear localization signal containing peptides specific for the leukemic stem cell phenotype CD123+CD131- for leukemia detection and Auger electron radioimmunotherapy*
Jeffrey V. Leyton, University of Toronto, Toronto, Ontario, Canada
 

9:30 - 11:00 am Exhibitor Hours
10:00 - 10:30 am Break
10:30 am - 12:30 pm

Plenary Session 2: Imaging Tumor Microenvironment, Stroma, Metastatic Niche - Randle Ballroom DE
Session Chairperson:  Zena Werb, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA

Imaging contributions to the microenvironment to chemoresistance
Mikala Egeblad, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Imaging the tumor microenvironment: An ever-changing landscape 
Zaver M. Bhujwalla, Johns Hopkins University School of Medicine, Baltimore, MD

A critical evaluation of methods to image tumor hypoxia
Mark W. Dewhirst, Duke University Medical Center, Durham, NC

Molecular imaging of the pre-metastatic niche in the lungs of a metastatic mouse model of breast cancer*
Wissam Beaino, University of Pittsburgh, Pittsburgh, PA
 

12:30 - 2:30 pm Poster Session A with Lunch - Randle Ballroom A/B/C
2:30 - 4:00 pm

Short Talks from Proffered Abstracts                                                                                              
Junior Investigator Session Randle Ballroom D/E

A novel diagnostic strategy for PET to define the clinical significance of the magnitude of target inhibition for therapies suppressing PI3K pathway signaling in renal cell carcinoma*
Michael G. Doran, Memorial Sloan-Kettering Cancer Center, New York, NY

Imaging secreted proteases in metastatic prostate cancer using novel human antibodies*
Aaron M. LeBeau, University of California, San Francisco, CA
 
Imaging apoptosis with positron emission tomography: Bench-to-bedside development of the caspase-3/7-specific radiotracer [18F]ICMT-11*
Quang-De Nguyen, Comprehensive Cancer Imaging Centre Imperial College London, London, England

Optical detection of viable tumor cells in liquid biopsies and their therapy in body fluids with oncolytic vaccinia virus*
Huiqiang Wang, Genelux Corp., San Diego, CA

An Improved Non-Invasive Imaging Method for the Assessment of Changes in Tumor Microstructure Using Temporal Diffusion Spectroscopy MRI*
Junzhong Xu, Vanderbilt University, Nashville, TN
 
2:30 - 4:30 pm Exhibitor Hours
4:15 - 6:15 pm

Plenary Session 3: Imaging Immune Cell Migration and Function in vivo - Randle Ballroom D/E
Session Chairperson: Christopher H. Contag, Stanford University School of Medicine, Stanford, CA

Imaging cancer and the immune response with positron emission tomography
Owen N. Witte, University of California, Los Angeles, CA

Imaging the role of the immune system during oncogene induced tumorigenesis
Dean W. Felsher, Stanford University School of Medicine, Stanford, CA

FLT-PET imaging for early identification of antigen-specific immune responses in cancer patients 
Jolanda de Vries, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands

Novel probe for non-invasive detection of tumor associated inflammation*
Brooke Helfer, Celsense Inc., Pittsburgh, PA

 
March 1, 2013
Time Session Title
7:00 - 8:00 am Continental Breakfast
8:00 - 10:00 am

Plenary Session 4: Cancer Metabolism and Tumor Physiology - Randle Ballroom D/E
Session Chairperson:  Steven M. Larson, Memorial Sloan-Kettering Cancer Center, New York, NY      

Metabolic imaging in cancer: What should we look for?
Ralph J. DeBerardinis, UT Southwestern Medical Center, Dallas, TX

The emerging role of hyperpolarized 13C MR in cancer imaging
John Kurhanewicz, University of California, San Francisco, CA

Imaging abnormal metabolism in cancer: Association with an altered tumor microenvironment, immunological dysfunction, and a propensity to develop metastases
Ronald Blasberg, Memorial Sloan-Kettering Cancer Center, New York, NY 

Non-invasive imaging of tumor glycogen storage by 18F-NFTG positron emission tomography*
Timothy Witney, Imperial College London, London, England

9:30 am - 2:00 pm Exhibitor Hours
10:00 - 10:30 am Break
10:30 am - 12:30 pm

Plenary Session 5: Innovative Therapies Guided by Imaging - Randle Ballroom D/E
Session Chairperson:  Kimberly A. Kelly, University of Virginia, Charlottesville, VA

Expediting translation of optical imaging into the clinic 
Go van Dam, Groningen University Medical Center, Groningen, The Netherlands

Imaging of oncolytic viral therapies of cancer
Stephen H. Thorne, University of Pittsburgh Cancer Institute, Pittsburgh, PA

Image-guided siRNA and miRNA therapies
Anna V. Moore, Massachusetts General Hospital, Charlestown, MA

99mTc-etarfolatide (EC20) SPECT imaging for the identification of ovarian and non-small cell lung cancer patients who are most likely to benefit from folate-receptor targeted agent vintafolide (EC145)*
Phillip H. Kuo, University of Arizona, Tucson, AZ

Image-guided treatment of pancreatic cancer using Cathepsin E-activatable prodrug*
Ching-hsuan Tung, The Methodist Hospital Research Institute-Weill Cornell Medical College, Houston, TX

12:30 - 2:00 pm Lunch on own/Free Time
2:00 - 4:00 pm

Plenary Session 6: Can Imaging Refine the “Omics of Cancer?” - Randle Ballroom D/E
Session Chairperson: David Piwnica-Worms, Washington University School of Medicine, St. Louis, MO

Cancer genomic and systems heterogeneity: Characterization and Challenges 
David R. Piwnica-Worms, Washington University School of Medicine, St. Louis, MO

Radiomics: Informing cancer heterogeneity 
Robert J. Gillies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Predictive computational models of cancer metabolism at the genome-scale
Jason Papin, University of Virginia, Charlottesville, VA

Molecular-genetic imaging of prostate cancer*
Akrita Bhatnagar, Johns Hopkins University, Baltimore, MD

4:15 - 5:15 pm Debate and Panel Discussion - Randle Ballroom D/E
Session Chairperson:  Jason S. Lewis, Memorial Sloan-Kettering Cancer Center, New York, NY
 

Clinical hyperpolarized MR in vivo - Pros and cons, human feasibility and limits
John Kurhanewicz, University of California, San Francisco, CA;
Thomas Budinger, Lawrence Berkeley National Laboratory, Berkeley, CA

5:15 - 7:00 pm Poster Session B and Reception - Randle Ballroom A/B/C
 
March 2nd, 2013
Time Session Title
7:00 - 8:00 am Continental Breakfast
8:00 - 10:00 am

Plenary Session 7: Imaging Signaling and Developmental Pathways in Cancer - Randle Ballroom D/E
Session Chairperson:  Hisataka Kobayashi, National Cancer Institute, Bethesda, MD

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
Atsushi Miyawaki, RIKEN Brain Science Institute, Wako, Saitama, Japan

Can mouse cancer models improve clinical medicine?
David A. Tuveson, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Imaging signaling pathways and tumor-stromal interactions in cancer metastasis 
Yibin Kang, Princeton University, Princeton, NJ

10:00 - 10:15 am Break
10:15 am - 12:15 pm

Plenary Session 8: Infectious Agents and Cancer: Understanding Cancer Causes and Converting into Cancer Cures - Randle Ballroom D/E
Session Chairperson: Martin G. Pomper, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD

Location, location, location- Visualizing interactions between Helicobacter pylori and the epithelium of the gastric glands 
Manuel R. Amieva, Stanford University, Palo Alto, CA

Tumor-targeted oncolytic adenovirus and monitoring of its replication in vivo
Masato Yamamoto, University of Minnesota, Minneapolis, MN

Ligand-directed therapy and molecular imaging based on in vivo phage display technology 
Renata Pasqualini, University of Texas MD Anderson Cancer Center, Houston, TX

12:15 pm Departure

**Agenda updated February 22, 2013