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MI: Making a Difference

January 28, 2013

18F-ISO-1 shows promise for imaging cell proliferation

Molecular Imaging

The first human study of the cell proliferation marker F18-ISO-1 indicated its safety and feasibility and suggested it may be used to stratify patients into high and low Ki-67 proliferative groups. The study was published online Jan. 28 in The Journal of Nuclear Medicine .

Measurements of cell proliferation can be used to predict and determine response to therapy and may inform the development of new agents. F18-FLT, a PET proliferation marker, underestimates the proliferative status of solid tumors. Ki-67 provides a marker for all phases of the cell cycle, but it requires a biopsy specimen or surgical resection, which is not possible for all tumors. Consequently, there is a need for a noninvasive means to measure the proliferative status of solid tumors.

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